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Innate Immun (2010) 16:6779.10.1177/1753425909105317 76 ZhangASEnnsCA

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Up-regulation of endogenous antioxidants is vital in combating oxidative stress Glutathione is the most abundant and versatile endogenous antioxidant Increasing glutathione remains a promising therapeutic strategy to slow or prevent MCI and Alzheimer disease . In addition to fighting cognitive decline, the antioxidant effects of glutathione also support strong mental health